A graftable LDV peptidomimetic: design, synthesis and application to a blood filtration membrane |
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| Authors: | Momtaz Maryam Rerat Vincent Gharbi Sonia Gérard Estelle Pourcelle Vincent Marchand-Brynaert Jacqueline |
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| Institution: | Unité de Chimie Organique et Médicinale, Université catholique de Louvain, 1 place Louis Pasteur, B-1348 Louvain-la-Neuve, Belgium. |
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| Abstract: | A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenyl-propionic acid, as alpha(4)beta(1) (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention. |
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