Enhancement of the depressant action of hexobarbital by tranquilizers in mice |
| |
| Authors: | A B Richards R B Forney F W Hughes |
| |
| Affiliation: | 1. Department of Pharmacy Practice, West Coast University School of Pharmacy, Los Angeles, CA, United States;2. Department of Pharmaceutical and Biomedical Sciences, Touro College of Pharmacy, New York, NY, United States |
| |
| Abstract: | Sleeping time, immobility time and arousal time were measured in mice after hexobarbital as a means of separating the different depressant characteristics of this drug in combination with certain tranquilizers.Enhancement of this barbiturate hypnosis was shown by the drugs, chlorpromazine, reserpine, meprobamate and hydroxyzine. The sedation calculated from these measurements was either inhibited or unaffected by these tranquilizers. Arousal time appears to be a critical measurement of the hypnotic property of a drug. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
