Vimentin expression in human squamous carcinoma cells: relationship with phenotypic changes and cadherin-based cell adhesion |
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Authors: | Islam S Kim J B Trendel J Wheelock M J Johnson K R |
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Institution: | Department of Biology, University of Toledo, Ohio. |
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Abstract: | Phenotypic changes resembling an epithelial-to-mesenchymal transition often occur as epithelial cells become tumorigenic. Two proteins that have been implicated in this process are vimentin and N-cadherin. In this study, we sought to establish a link between expression of vimentin and N-cadherin as oral squamous epithelial cells undergo a morphologic change resembling an epithelial-to-mesenchymal transition. We found that N-cadherin and vimentin did not influence the expression of one another. |
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