Segregation and linkage analysis. |
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| Authors: | R C Elston |
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| Affiliation: | Department of Biometry and Genetics, Louisiana State University Medical Center, New Orleans 70112. |
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| Abstract: | Computer programs are available in the software package SAGE to perform a variety of segregation and linkage analyses used by human geneticists. These methods are designed specifically to uncover major gene segregation in pedigree data coming from non-inbred populations. With the aid of a closely linked polymorphic marker, they can detect a locus that contributes as little as 10% to the variation of a quantitative trait in a pedigree sample of several hundred individuals. |
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| Keywords: | major genes maximum likelihood regressive models sage sib-pair methods |
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