Localization patterns of fibroblast growth factor 1 and its receptors FGFR1 and FGFR2 in postnatal mouse retina |
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Authors: | Elisabetta Catalani Silvia Tomassini Massimo Dal Monte Luigi Bosco Giovanni Casini |
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Institution: | (1) Dipartimento di Scienze Ambientali, Università della Tuscia, Largo dell’Università snc, Blocco D, 01100 Viterbo, Italy;(2) Dipartimento di Ecologia e Sviluppo Economico Sostenibile, Università della Tuscia, Viterbo, Italy;(3) Dipartimento di Biologia, Università di Pisa, Pisa, Italy |
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Abstract: | Fibroblast growth factors (FGFs) exert basic functions both during embryonic development and in the adult. The expression
of FGFs and their receptors has been reported in mammalian retinas, although information on the organization of the FGF system
is still incomplete. Here, we report a detailed double-label immunohistochemical investigation of the localization patterns
of FGF1 and its receptors FGFR1 and FGFR2 in adult and early postnatal mouse retinas. In adult retinas, FGF1 is localized
to ganglion cells, horizontal cells, and photoreceptor inner and outer segments. FGFR1 is found in ganglion cells and Müller
cells, whereas FGFR2 is primarily located in ganglion cells, the nuclei of Müller cells, and glycine-containing amacrine cells.
During postnatal development, the patterns of FGF1, FGFR1, and FGFR2 immunostaining are similar to those in the adult, although
transient FGF1-expressing cells have been detected in the proximal inner nuclear layer before eye opening. These patterns
are consistent with a major involvement of FGF1, FGFR1, and FGFR2 in ganglion cell maturation (during development) and survival
(in the adult). Moreover, FGF1 may affect amacrine cell development, whereas Müller cells appear to be regulated via both
FGFR1 and FGFR2 throughout postnatal life. In immature retinas, large numbers of amacrine cells, including those containing
calbindin and glycine, display both FGF1 and FGFR2 immunoreactivities in their nuclei, suggesting an action of FGF1 on FGFR2
leading to the maturation of these amacrine cells during a restricted period of postnatal development.
This work was supported by funding from the Italian Ministry of Education. |
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Keywords: | Development Retinal ganglion cells Amacrine cells Horizontal cells Müller cells Mouse (C57BL/6) |
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