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Combination of an antiviral drug and immunomodulation against hepadnaviral infection in the woodchuck model |
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| Authors: | Lu Mengji Yao Xin Xu Yang Lorenz Heike Dahmen Uta Chi Haidong Dirsch Olaf Kemper Thekla He Lifang Glebe Dieter Gerlich Wolfram H Wen Yumei Roggendorf Michael |
| Institution: | Institut für Virologie, Universitätsklinikum Essen, Essen, Germany,1. Department of Molecular Virology, Medical Center of Fudan University, Shanghai, People''s Republic of China,2. Institut fuer Medizinische Virologie, Justus-Liebig-Universitaet Giessen, Giessen,3. Klinik für Allgemeine Viszeral- und Transplantationschirugie, Univesitaetsklinkum Essen, Essen,4. Institut fuer Pathologie, Universitaetsklinkum Köln, Cologne, Germany5. |
| Abstract: | The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including antiviral chemotherapy and immunomodulation. This hypothesis was tested in the woodchuck model by a combination of lamivudine pretreatment and subsequent immunizations of woodchucks chronically infected with woodchuck hepatitis virus. The immunizations were performed with DNA vaccines or antigen-antibody immune complexes (IC)/DNA vaccines. Immunizations with IC/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection. |
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