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Isolation and identification of a fucose-containing ganglioside from bovine thyroid gland |
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| Authors: | Bruce A. Macher Tadeusz Pacuszka Brian R. Mullin Charles C. Sweeley Roscoe O. Brady Peter H. Fishman | |
| Affiliation: | 1. Department of Biochemistry, Michigan State University, East Lansing, MI 48824, USA;2. Developmental and Metabolic Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20014, USA;3. Department of Pathology, Cleveland Methopolitan General Hospital, Cleveland, OH 44109 U.S.A. | |
| Abstract: | Bovine thyroid glands are known to contain a complex array of gangliosides. One of the predominant gangliosides was isolated and analyzed by gas-liquid chromatography and mass spectrometry. The carbohydrate composition was fucose, N-acetylneuraminic acid, galactose, N-acetylgalactosamine, and glucose in molar ratios of 1:1:2:1:1. The structure of the ganglioside was identified as:  | |
| Keywords: | Ganglioside Fucose Carbohydrate analysis (Bovine thyroid gland) Fuc fucose trimethylsiyl Galβ1-3GalNacβ1-4Gal[3-2αAcNeulβ1-4G1cβ1-1ceramide GalNACβ1-4Gal[3-2αAcNeulβ1-4Glcβ1-ceramide AcNeuα2-3Galβ1-4Glcβ1-1ceramide AcNeuα2-3Galβ1-3GalNAcβ1-4Gal[3-2αAcNeu]β1-4Glcβ1-1ceramide AcNeuα2-8AcNeuα2-3Galβ1-4Glcβ1-1ceramide | |
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