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Increase in liver acid lipase of thyroidectomized rats by thyroid hormones and its inhibition by actinomycin D |
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| Authors: | Paul M. Coates Herbert Lau Ladislav Krulich Spencer A. Brown Otakar Koldovsky |
| Affiliation: | 1. The Joseph Stokes, Jr. Research Institute, Children''s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA;2. Department of Physiology, University of Texas Health Science Center, Dallas, TX 75235 U.S.A. |
| Abstract: | Acid lipase activity in the livers of thyroidectomized rats is increased by administration of L-thyroxine. The response is dose-dependent and can be demonstrated within 12 h after treatment. L-Triiodothyronine also evokes a rapid increase in acid lipase activity, and this increase can be inhibited by co-administration of actinomycin D. |
| Keywords: | Thyroidectomy Thyroid hormone Lipase activity Actinomycin D L-triiodothyronine L-thyroxine TSH thyroid stimulating hormone |
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