Variations in mitochondrial monoamine oxidase during progressive starvation in the brain of developing rats |
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Authors: | G. Ismahan H. Parvez S. Parvez |
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Affiliation: | Neuropharmacology Unit, University of Paris XI, Bat. 440-PC-013, 91405 Orsay France |
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Abstract: | Effects of progressive starvation of 12, 24, 48 and 60 h upon brain mitochondrial monoamine oxidase activity were studied. The enzyme activity was determined by three different substrates: 14C-labeled tryptamine, dopamine and kynuramine. With dopamin as substrate, the enzyme activity showed decline during 24 and 48 h starvation. Monoamine oxidase when determined by tryptamine as the substrate, showed a decreased after 60 h of starvation. The use of kynuramine as substrate also produced a decrease in enzyme activity after 48 and 60 h of starvation. Refeeding the 60-h-starved rats for the following 24 h resulted in further decrease of monoamine oxidase activity of brain mitochondria from the 60 h starved values. The results suggest that oxidative deamination of biogenic amines is greatly inhibited during progressive starvation and remains low even after feeding the 60 h starved rats for 24 h. |
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Keywords: | Monoamine oxidase Starvation Tryptamine Kynuramine Dopamine (Brain mitochondria) PPO 2,5-diphenyloxazole POPOP 1,4-bis-(5-phenyloxaloy-2)-benzene |
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