A comparison of the activities of aryl hydrocarbon monooxygenase in liver microsomes from mice of different strains during prolonged 3,4-benzo(a)pyrene administration |
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Authors: | Ilya B Tsyrlov Vyacheslav V Lyakhovich |
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Institution: | Department of Biochemistry, Institute of Experimental and Clinical Medicine, Academy of Medical Science of the U.S.S.R., Siberian Branch, Novosibirsk 630091 U.S.S.R. |
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Abstract: | The content and activity of the components of liver microsomal aryl hydrocarbon monooxygenase system change biphasically during long-term 3,4-benzo-(a)pyrene administration to C57BL/6 mice as well as to (C57BL/6 × DBA/2)F1 hybrids. The first activity peak (4–14 days) is associated with the induction of aryl hydrocarbon monooxygenase by 3,4-benzo(a)pyrene; the second peak (70–84 days) is related to noninductive mechanism. In DBA/2 mice, the second peak is absent while the slight increase in aryl hydrocarbon monooxygenase activity observed on days 14–28 indicated the aberrant inductive capacity of 3,4-benzo(a)pyrene under its prolonged administration. It is suggested that the weak sensitivity to the blastogenesis caused by 3,4-benzo(a)pyrene observed in C57BL/6 mice and in (C57BL/6 × DBA/2)F1 hybrids is due to the high level of liver aryl hydrocarbon monooxygenase activity at the time of tumor appearance. |
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Keywords: | 3 4-Benzo(a)pyrene Aryl hydrocarbon monooxygenase Carcinogenesis (Mouse liver microsome) |
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