A heat-stable protein inhibitor of cyclic 3′,5′-nucleotide phosphodiesterase |
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| Authors: | Yung Pin Liu Vernon G. Wong |
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| Affiliation: | 1. Clinical Pharmacology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014, USA;2. Department of Ophthalmology, Georgetown University Medical Center, Washington, DC 20007 U.S.A. |
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| Abstract: | A heat-stable, non-dialyzable inhibitory factor of cyclic nucleotide phosphodiesterase was detected in and partially purified from bovine retina. The factor appears to be a protein, since the inhibitory activity was abolished by trypsin digestion but not by DNAase or RNAase treatment. The protein inhibitor from bovine retina effectively inhibits the Ca2+-independent phosphodiesterase from several sources, including bovine retina, bovine rod outer segment, and a human lymphoblastic leukemia cell line, indicating lack of tissue and species specificity. |
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| Keywords: | Phosphodiesterase inhibitor Cyclic nucleotide (Bovine retina, Lymphoblastic leukemia cell) |
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