Role of cytoskeletal elements in cytochalasin E-induced superoxide production by human polymorphonuclear leukocytes |
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| Authors: | Akira Nakagawara Shigeki Minakami |
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| Affiliation: | 1. Department of Surgery, Division of Pediatric Surgery Kyushu University School of Medicine, Fukuoka 812, Japan;2. Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812, Japan |
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| Abstract: | The release of superoxide anions from human polymorphonuclear leukocytes induced by cytochalasin E was greatly enhanced by the pretreatment of the cells either with deuterium oxide or with concanavalin A. Colchicine, vinblastine and cyclic AMP inhibited the release. Cytochalasins A and B also suppressed the superoxide release. These observations suggest the involvement of microfilament-microtubule system in the production and release of superoxide anions induced by cytochalasin E. |
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| Keywords: | Cytochalasin E Superoxide ion Microtubule Microfilament Phagocytosis (Leukocyte Cytoskeletal element) |
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