Changes in lung lysyl oxidase activity in streptozotocin-diabetes and in starvation |
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Authors: | Ashwin M. Madia S.Jaime Rozovski Herbert M. Kagan |
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Affiliation: | Department of Biochemistry and the Division of Diabetes and Metabolism, Department of Medicine, Boston University School of Medicine, Boston, MA, U.S.A. |
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Abstract: | The effects of streptozotocin-induced diabetes and of starvation on the lysyl oxidase activity of rat lung were investigated. Enzyme activity was elevated 2–3 fold in the lungs of streptozotocin-diabetic rats. In contrast, starvation of rats produced a rapid loss of lung lysyl oxidase activity, with levels approximating 25% of control values after 48–72 h of starvation. Enzyme activity was essentially fully restored to control values upon refeeding the 48-h starved animals for 3 h. These studies demonstrate the responsiveness of lysyl oxidase to these physiological states and suggest a component, enzymatic basis of change in lung function known to occur in the diabetic state. |
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Keywords: | Lysyl oxidase Streptozotocin diabetes Starvation (Lung) |
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