Synthesis of imidazo[4,5-d][1,3]thiazine ribosides and related compounds of biological interest |
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Authors: | C Kaneko H Matsumoto S Hara T Takeuchi T Mori K Ikeda Y Mizuno |
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Institution: | Minophargen Research Laboratory, Kanagawa, Japan. |
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Abstract: | Several tri-O -acetyl-1-beta-D -ribofuranosyl- and 2-acetoxyethoxymethylimidazo4,5-d]1,3]thiazine derivatives 5-10 were synthesized from imidazo4,5-d]1,3]thiazine 4 and tetra-O -acetyl-beta-D -ribofuranose or 2-acetoxyethoxymethyl acetate by fusion method. In each case, depending on the substituent on position 5 of thiazine skeleton, only N3 isomer or both N1 and N3 isomers (in different ratios) were obtained. |
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