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Inhibin immunoreactivity in gonadal and non-gonadal tumors |
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| Authors: | FH De Jong AJ Grootenhuis J Steenbergen FJ van Sluijs JA Foekens FJW ten Kate JW Oosterhuis SWJ Lamberts JGM Klijn |
| Institution: | a Department of Biochemistry (Division of Chemical Endocrinology), Erasmus University Rotterdam, The Netherlands b Department of Internal Medicine Erasmus University Rotterdam, The Netherlands c Department of Pathology, Erasmus University Rotterdam, The Netherlands d Department of Clinical Sciences of Companion Animals, State University Utrecht, The Netherlands e Division of Endocrine Oncology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands f Department of Pathology, State University Groningen, The Netherlands |
| Abstract: | Inhibin immunoreactivity was estimated in a number of gonadal and non-gonadal tumors. Dog Sertoli cell tumors and human granulosa cell and Leydig cell tumors contained high concentrations of inhibin-like material. Levels, comparable with those in normal testes and ovaries were detected in human testicular non-seminomas and in ovarian cystadenomas, thecomas and adenofibromas. No activity was found in human testicular Sertoli/Leydig cell tumors and seminomas and in ovarian adenocarcinomas, teratomas and a dysgerminoma. Furthermore, human adrenal cortical tissue (tumor and hyperplastic adrenal) contained inhibin immunoreactivity. No activity was found in human tumors of the stomach, gut, liver, kidney, pancreas and mammary gland or in meningiomas. It is concluded that inhibin is not a good marker for specific gonadal tumors. Inhibin might have intratumor actions a growth or differentiation factor. |
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