The viral potassium channel Kcv: structural and functional features |
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| Authors: | Gazzarrini Sabrina Severino Maria Lombardi Mara Morandi Marzia DiFrancesco Dario Van Etten James L Thiel Gerhard Moroni Anna |
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| Institution: | Department of Biology, CNR-IBF Unità di Milano, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy. |
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| Abstract: | The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels. |
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| Keywords: | K+ channel Kcv PBCV-1 Chlorella virus |
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