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Regulation of NAD- and NADP-linked isocitrate dehydrogenase by thyroxine in the brain and liver of female rats of various ages |
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| Authors: | R N Yadav |
| Affiliation: | 1. School of Management and Economics, Beijing Institute of Technology, Beijing, 100081, China;2. Alma Mater Europaea ECM, Maribor, Slovenia;3. DCU Business School Dublin City University, Ireland;1. Animal Welfare Research Group, Norwegian University of Life Sciences (NMBU), Faculty of Veterinary Medicine, Department of Production Animal Clinical Science, Oslo, Norway;2. Department of Animal Science, Aarhus University, Blichers Allé 20, DK-8830, Tjele, Denmark;3. Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), N-1432 Ås, Norway;4. Animalia, Norwegian Meat and Poultry Research Centre, Oslo, Norway;5. Behavioural Ecology Group, Wageningen University, Wageningen, The Netherlands |
| Abstract: | The specific activity of NAD- and NADP-linked isocitrate dehydrogenase and their regulation by thyroxine in the brain and liver of female rats of various ages were studied with the ultimate goal of better understanding the decreased physiological functioning of the brain and liver during old age. Both thyroidectomy and thyroxine treatment have differential age-dependent effects on the activities of these enzymes in both tissues. The activity of NAD-ICDH decreases whereas both cytoplasmic and mitochondrial NADP-ICDH increase simultaneously following thyroidectomy. Thyroxine administration induces NAD-ICDH and depresses NADP-ICDH. The degree of induction and/or repression is lowest in old rats. These effects of thyroxine are actinomycin D sensitive in both the tissues of rats. |
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