乳腺导管原位癌患者钼靶摄影表现与ki-67、PR、ER、HER-2表达的相关性

目的探讨乳腺导管原位癌(DCIS)患者钼靶摄影表现与ki-67、PR、ER、HER-2表达的相关性。方法回顾性分析2010年1月~2016年1月入住三明市第二医院普外科经病理检查明确诊断为DCIS的患者82例,收集82例DCIS患者的年龄、身高、体重、是否绝经、病理资料、乳腺钼靶等资料,根据乳腺钼靶摄影有无钙化分为钙化组与非钙化组,并分析两组患者的年龄、体质指数、是否绝经、乳腺钼靶表现与DCIS患者ki-67、PR、ER、HER-2表达的相关性。结果非钙化DCIS患者ki-67阳性率为58.3%(21/36),PR阳性率为52.8%(19/36),ER阳性率为55.6%(20/36),HER-2阳性率为38.7%(14/36),钙化DCIS患者的ki-67、HER-2阳性率较非钙化患者均明显升高。随着年龄的增长,DCIS患者的ki-67阳性表达率降低,HER-2阳性表达率升高;随着BMI的增加,DCIS患者的PR、ER阳性表达率亦逐渐升高;而未绝经的DCIS患者PR、ER阳性表达率较已绝经患者均明显升高。结论乳腺钼靶摄影表现为钙化的DCIS患者ki-67高表达,其HER-2亦高表达,以上特征可在一定程度上指导临床制定个体化诊治方案。

Correlation of mammographic characteristics with expressions of Ki-67, ER,PR,HER-2in breast ductal carcinoma in situ

Objective To investigate the correlation of mammographic characteristics with expressions of ki‐67 , ER ,PR ,HER‐2 in breast ductal carcinoma in situ . Methods A total of 82 patients who were confirmed with breast ductal carcinoma in situ by pathology in the second hospital of sanming .We collected the indicators as age , height ,weight ,menopausal status ,pathological files ,mammographic characteristics ,and analyze its correlation with expressions of ki‐67 ,ER ,PR ,HER‐2 . Results The positive incidence of ki‐67 ,PR ,ER ,HER‐2 in the non‐calci‐fication group were 58 .3% ,52 .8% ,55 .6% and 38 .7% .Compared with the non‐calcification group ,the positive in‐cidence of ki‐67 and HER‐2 in the calcification group were significantly increased (allP<0 .05) .With the age in‐creased ,the positive incidence of ki‐67 was decreased ,but the positive incidence of HER‐2 was increased(P< 0 . 05) .With the body mass index increased ,the positive incidence of PR ,ER were significantly increased(P<0 .05) . Compared with the patients who were menopause ,the positive incidence of PR ,ER in the patients who were non‐menopause were significantly increased(P<0 .05) . Conclusion ki‐67 and HER‐2 are highly expressed in ductal carcinoma in situ with mammographic calcification characteristics ,which may provide guidance for the individual‐ized diagnosis and treatment in clinic .