Ion channels as therapeutic antibody targets |
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Authors: | Catherine J. Hutchings Theodore G. Clark |
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Affiliation: | 1. TetraGenetics Inc, Arlington Massachusetts, USA;2. Department of Microbiology and Immunology, Cornell University, Ithaca New York, USA |
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Abstract: | It is now well established that antibodies have numerous potential benefits when developed as therapeutics. Here, we evaluate the technical challenges of raising antibodies to membrane-spanning proteins together with enabling technologies that may facilitate the discovery of antibody therapeutics to ion channels. Additionally, we discuss the potential targeting opportunities in the anti-ion channel antibody landscape, along with a number of case studies where functional antibodies that target ion channels have been reported. Antibodies currently in development and progressing towards the clinic are highlighted. |
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Keywords: | Ion channel antibodies biologics therapeutic |
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