Three types of sesquiterpenes from rhizomes of Atractylodes lancea |
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Authors: | Wang He-Xiang Liu Chun-Mei Liu Quan Gao Kun |
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Institution: | State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, PR China. |
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Abstract: | Eight sesquiterpenes, including four guaiane-types containing an interesting epoxy unit (1-4), a rare tricyclic carbon skeleton-type (5) and three eudesmane-types (6-8), along with five known compounds, were isolated from rhizomes of Atractylodes lancea. The structures and relative configurations of 1-8 were determined by analysis of spectroscopic data, and the absolute configuration of 8 was assigned by application of the CD technique. Compounds 1, 2 and 4 were evaluated for their cytotoxic effects against P388 and A549 cells, but all were inactive. Possible biosynthetic pathways for sesquiterpenes (1-8) were discussed. |
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Keywords: | Atractylodes lancea Compositae Sesquiterpene Guaiane Eudesmane Cytotoxicity |
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