Inhibition of Cathepsin B1 by E-64, a Thiol Proteinase Inhibitor,and Its Derivatives |
| |
Authors: | Takashi Inaba Yaoki Hirayama Norihisa Fujinaga |
| |
Institution: | Laboratory of Biological Chemistry, Faculty of Agriculture, Saga University, Saga 840, Japan |
| |
Abstract: | Four formaldehyde-resistant yeasts were isolated from soil. Three were tentatively identified as Debaryomyces vanriji and one as Trichosporon penicillatum. These yeasts almost completely consumed formaldehyde at 0.15 to 0.55% in growth medium containing glucose as carbon source, but the carbon of formaldehyde was not incorporated into the cell constituents. In formaldehyde-containing medium, yeast growth occurred after formaldehyde consumption. The yeasts showed relatively high activities of formaldehyde dehydrogenase, S-formylglutathione hydrolase and formate dehydrogenase. The resistance to formaldehyde is attributed to detoxification by oxidation. |
| |
Keywords: | Myrsine seguinii anti-inflammatory TPA-induced edema |
|
|