Photodynamic Activity of Compounds Structurally Related to Cercosporin |
| |
| Authors: | F. Macrì A. Vianello |
| |
| Affiliation: | Centro di Studio dei Problemi Fitopatologici delta Barbabietola da Zucchero, CNR, Unità di Ricezca del Progetto Finalizzato Chimica Fine e Secondaria, Istituto di Patologia Vegetale, Università di Padova, I-35100 Padova, Italy |
| |
| Abstract: | The photodynamic activity of three compounds structurally related to cercosporin (iso-cercosporin, phleichrome, iso-phleichrome) and rubellin, a pigment possessing an anthra-quinone-like structure, was studied. As previously reported for cercosporin, iso-cercosporin, phleichrome, iso-phleichrome and rubellin, when irradiated by an incandescent lamp, induced oxygen uptake and malondialdehyde (MDA) formation in pea stem and rat liver mitochondria and microsomes. All these compounds were also capable of inhibiting MDA formation induced by the peroxidizing system ascorbate-FeSO4. Circumstantial evidence suggests that the compounds, as shown for cercosporin, induce a lipoperoxidative degradation of the polyunsaturated fatty acids of cell membranes when irradiated by light, but at the same time, they are able to lower the lipoperoxidation induced by ferrous ions. |
| |
| Keywords: | |
|
|
