Purification and Properties of Allothreonine Aldolase from Maise Seedlings |
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Authors: | Tutomu Masuda Mitsuko Yoshino Izumi Nishizaki Akira Tai Hiroshi Ozaki |
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Affiliation: | 1. Shitennoji Junior College, Hanyuno, Habikino 583, Japan;2. Institute for Protein Research, Osaka University, Suita, Osaka 565, Japan |
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Abstract: | In order to elucidate the structure-activity relationship of griseofulvin (1), (±)-6′-demethyl analog (3), 2′-demethoxy-6′-demethyldihydro analog (4), (±)-dechloro-6′-ethyl analog (5), (±)-dechloro-6′-epi-ethyl analog (6), (±)-6′-ethyl analog (7) and (±)-6′-epi-ethyl analog (8) were synthesized by a Diels-Alder cycloaddition of alkylidene ketones (16, 17, 18, 19 and 20) with modified 1,3-butadienes (21 or 22). Their biological activities were examined against fungi. |
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Keywords: | 100-kilodalton mosquitocidal toxin synergism Bacillus sphaericus Cyt1Aa resistance |
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