New Aspartate Aminotransferase Inhibitor (Gostatin) Produced by Streptomyces sumanensis nov. sp., NK-23 |
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| Authors: | Sawao Murao Toyokazu Nishino Noriko Katayama Hiroto Nagano |
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| Affiliation: | Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka 591, Japan |
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| Abstract: | An isopropenyl ( = 3,3-dimethylallyl) 3-methoxyflavone (1) and its hydrate (5) were isolated from the roots of yellow lupin, Lupinus luteus L. cv. Topaz. Their structures were unambiguously determined to be 5,7,4′-trihydroxy-3-methoxy-6-(3,3-dimethylallyl)flavone (1) and 5,7,4′-trihydroxy-6-(3-hydroxy-3-methylbutyl)-3-methoxyflavone (5) by a combination of chemical and spectroscopic methods, and the new flavones were named topazolin and topazolin hydrate, respectively.Antifungal tests against the growth of Cladosporium herbarum indicated that, in spite of its phenolic nature and the possession of an isopentenyl sidechain, topazolin (1) had only weak fungitoxic activity. |
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