Effect of Ribocitrin on Glucan Synthesizing Enzymes of Streptococcus mutans E49 |
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| Authors: | Masachika Takashio Yoshiro Okami |
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| Institution: | Institute of Microbial Chemistry, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan |
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| Abstract: | Enzymes participating in glucan synthesis by Streptococcus mutans E49 were separated into two fractions with distinctly different activities by chromatography on DEAE Bio-Gel A. The insoluble glucan (IG) was revealed to be formed by the coupling reaction of these two enzymes, dextransucrase (SGE), which synthesizes soluble glucan from sucrose, and a glucan insolubilizing enzyme (IGE), which forms IG from soluble glucan.Ribocitrin was found to inhibit IG synthesis by inhibiting SGE. |
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| Keywords: | lactoferricin B minocycline monoacylglycerol Staphylococcus aureus bactericidal |
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