The Induction of Lipid Peroxidation in Rat Liver by Oral Intake of 9-Oxononanoic Acid Contained in Autoxidized Linoleic Acid |
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| Authors: | Shinsuke Minamoto Kazuki Kanazawa Hitoshi Ashida Gen-ichi Danno Masato Natake |
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| Institution: | 1. Department of Agricultural Chemistry, Kobe University, Nada-ku, Kobe 657, Japan;2. Department of Utilization of Biological Resources, Graduate School of Science and Technology, Nada-ku, Kobe 657, Japan |
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| Abstract: | A component in the autoxidation products of linoleic acid (LA) which induced the endogenous lipid peroxidation was searched for. Secondary autoxidation products (SP) of LA induced the production of thiobarbituric acid reactive substances (TBARS) in liver as well as the LA hydroperoxides stimulated. SP were separated chromatographically into some fractions which were administered orally to rats. One fraction composed mainly of 9-oxononanoic acid (9-ONA) markedly stimulated the TBARS production in liver. Authentic 9-ONA also increased the lipid peroxide level as determined by a new test, as well as the activities of glutathione peroxidase and reductase in liver. Thus, hepatic lipid peroxidation was induced by orally given 9-ONA which was present in the autoxidation products of LA. |
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