A New Antibiotic K-52B |
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Authors: | Motoo Shibata Masaru Uyeda Yutaka Kido Motoharu Kinoshita Fumiko Ishimaru Itsuko Hatanaka |
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Institution: | Laboratory of Medicinal Microbiology, Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan |
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Abstract: | A new antibiotic K-52B, different from K-52A, was isolated from the culture broth of Streptoverticillium roseoverticillatum subsp. albosporum, strain No. K-52. The antibiotic K-52B was thought to be a similar saccharide to K-52A from its physicochemical properties but differed from K-52A in the presence of nitrogen content. Antibiotic K-52B inhibited the growth of Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa on a chemically defined medium. The growth inhibition was, however, reversed by l-glutamine, l-glutamic acid, l-asparagine and l-aspartic acid. |
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Keywords: | Magnaporthe grisea Pyricularia oryzae appressorium formation cDNA subtraction differential library |
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