Isolation and Identification of a New Analogue of Aspergillic Acid Derived from Valine and Isoleucine

The biological activities of zinc and cadmium on Euglena gracilis grown in zinc deficient and sufficient media were examined- Cadmium was neither involved in the normal cell metabolism of E. gracilis under zinc deficient conditions, nor did not replace zinc, which is essential for the normal growth. More cadmium was incorporated into cells grown in zinc deficient media than in zinc sufficient ones, resulting in more toxic effects in zinc deficient media than in zinc sufficient ones. Cadmium effectively provoked abnormal cells under zinc deficient conditions, suggesting that the normal process of cell division was interrupted by cadmium.