Fungal Metabolism of Sorbic Acid |
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| Authors: | Satoshi Tahara Shin Kurogochi Masaki Kudo Junya Mizutani |
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| Affiliation: | Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan |
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| Abstract: | The metabolism of sorbic acid (S A) by 11 species of Mucor and 14 other fungi in addition to Mucor sp. A–73 were studied. All species of Mucor metabolized SA to trans-4-hexenol (4–HEL) without exception. The metabolic pathway was investigated precisely by using the resting cells of Mucor sp. A–73. The reduction of SA to 4–HEL by the fungus demanded glucose. The reduction of SA to sorbic alcohol (SAL) was catalyzed by the inducible enzymic system and that of SAL to 4–HEL by the constitutive enzyme. In the phosphate buffer, a part of 4–HEL produced from SA was further transformed into mono-trans-4-hexenyl phosphate by Mucor sp. A–73.The reductive action of the fungus upon several trans-2-alkenoic acids was also examined. |
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| Keywords: | Amorfrutin total synthesis Claisen rearrangement Amorpha fruticosa Glycyrrhiza acanthocarpa |
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