Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (*#x2212;)-Indolactam V |
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| Authors: | Kazuhiro Irie Nobuyuki Hagiwara Koichi Koshimizu Harukuni Tokuda Yohei Ito Hideo Hayashi |
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| Institution: | 1. Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan;2. Department of Microbiology, Faculty of Medicine, Kyoto University, Kyoto 606, Japan;3. College of Agriculture, University of Osaka Prefecture, Sakai 591, Japan |
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| Abstract: | New 14-O-derivatives of (?)-indolactam V, which has the basic ring-structure of teleocidins without the monoterpenoid moiety, were prepared and their Epstein–Barr virus early antigen (EBV-EA) inducing activity was tested. A series of 14-O-alkyl derivatives was far less active than (?)-indolactam V, but the 14-O-acyl derivatives showed a high EBV-EA inducing activity. These results suggest that the free hydroxyl group at C-14 plays an important role in inducing the EBV-EA, and that the activity of the acyl derivatives arises through hydrolysis of the ester groups. |
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