Structures of Cinnzeylanine and Cinnzeylanol,Polyhydroxylated Pentacyclic Diterpenes from Cinnamonum zeylanicum Nees |
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| Authors: | Akira Isogai Akinori Suzuki Saburo Tamura Shigeo Murakoshi Yuji Ohashi Yoshio Sasada |
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| Institution: | 1. Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo;2. Kanagawa Prefectural Institute for Sericultural Science, Ebina-shi, Kanagawa-ken;3. Laboratory of Chemistry for Natural Products, Tokyo Institute of Technology, Meguro-ku, Tokyo |
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| Abstract: | A bacterium isolated as resistant to alkyldimethylbenzylammonium chloride (benzalkonium chloride, BC) and tentatively identified as Enterobacter cloacae, was induced by BC to produce acidic polysaccharide. The optimum concentration of BC for production of the polysaccharide was 0.1% and the polysaccharide produced amounted to 1.0-2.0 mg per ml of culture broth. The best carbon and nitrogen sources for the polysaccharide production were glycerol and polypeptone.The acidic polysaccharide was consisted of fucose, galactose, glucose, glucuronic acid, pyruvate, and acetate, like colanic acid. The production of the acidic polysaccharide was not induced by the addition of trimethylbenzylammonium chloride and tetramethylammonium chloride, but it was induced by p-fluorophenylalanine, and the results are discussed. |
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| Keywords: | postprandial hyperglycemia inflammatory cytokine peripheral leukocytes α-glucosidase inhibitor dipeptidyl peptidase-4 (DPP-4) inhibitor |
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