Effect of 5-Phosphoribosyl-1-pyrophosphate on Crystalline Quinolinate Phosphoribosyltransferase Activities from Hog Kidney and Hog Liver |
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| Authors: | Katsumi Shibata Kazuo Iwai |
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| Affiliation: | 1. Food and Nutrition Laboratories, Faculty of Domestic Science, Teikoku Women’s University, Moriguchi, Osaka 570, Japan;2. Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan |
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| Abstract: | The pH profiles of crystalline quinolinate phosphoribosyltransferase (EC 2.4.2.19) activities from hog kidney and hog liver were found to vary according to 5-phosphoribosyl-1-pyrophosphate concentration. Both the kidney and liver enzyme activities were inhibited by 5-phosphoribosyl-1-pyrophosphate at an alkaline pH and physiological pH (pH 7.4) but not at an acidic pH. The inhibition by 5-phosphoribosyl-1-pyrophosphate was competitive for quinolinic acid. In the presence of 30% glycerol, both the kidney and liver enzyme activities were inhibited by 5-phosphoribosyl-1-pyrophosphate, even at an acidic pH. |
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| Keywords: | conjugated polyketone reductase aldoketo reductase asymmetric reduction Candida parapsilosis optically active alcohols |
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