Phytosterol from the Callus of Stevia Rebaudiana Bertoni |
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| Authors: | Kensuke Nabeta Teruyo Kasai Hiroshi Sugisawa |
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| Institution: | Department of Food Science, Faculty of Agriculture, Kagawa University, Miki-cho, Kagawa-ken, Japan |
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| Abstract: | We investigated the effect of 17β-estradiol (E2) on the expression of daintain/AIF-1, a marker of activated macrophages, in RAW264.7. E2 upregulated the protein and mRNA levels of daintain/AIF-1 in similar manners under physiological concentrations of 10?11 M to 10?7 M. The application of ICI 182,780, an estrogen receptor (ER) antagonist, attenuated E2-induced daintain/AIF-1 production, suggesting the involvement of ER in this process. |
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| Keywords: | 17β-estradiol (E2) daintain/AIF-1 upregulation estrogen receptor (ER) RAW264 7 macrophages |
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