Isolation and Structure of New Isocoumarins |
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| Authors: | Yoshio Furutani Hiroshi Naganawa Tomio Takeuchi Hamao Umezawa |
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| Affiliation: | Institute of Microbial Chemistry, 3–14–23, Kamiosaki, Shinagawa-ku, Tokyo, Japan |
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| Abstract: | Besides reticulol, the strain MD611-C6 produced two compounds which inhibited cyclic nucleotide phosphodiesterases [EC 3.1.4. C.] These substances were isolated and their structures were elucidated to be 8-hydroxy-6, 7-dimethoxy-3-hydroxymethyIisocoumarin (II) and 6, 8-dihyroxy-7-methoxy-3-hydroxymethylisocoumarin (III). Concentrations of II and III for 50% inhibition of cAMP phosphodiesterase were 3.97 × 10?4m and 1.26 × 10?8m, respectively. |
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| Keywords: | Bacillus stearothermophilus purine nucleoside phosphorylase pyrimidine nucleoside phosphorylase |
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