Ionophorous Properties of SY-1 (20-Deoxysalinomycin) in Rat Liver Mitochondri |
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| Authors: | Yukio Miyazaki Mitsuaki Mitani Noboru Ōtake |
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| Affiliation: | 1. Central Research Laboratories, Kaken Chemical Co., Ltd., 1-6-42, Jujodai, Kita-ku, Tokyo 114, Japan;2. Institute of Applied Microbiology,The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan |
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| Abstract: | SY-1 (20-deoxysalinomycin), a monocarboxylic polyether antibiotic closely related to salinomycin, caused a rapid release of previously accumulated alkali metal cations by valinomycin or monazomycin in rat liver mitochondria, and simultaneously reversed swelling of mitochondria.With a strict specificity for substrate and cation, SY-1 exhibited a property of inhibiting mitochondrial functions such as substrate oxidation, oxidative phosphorylation and ATP hydrolysis induced by valinomycin or monazomycin, In comparative study with salinomycin, SY-1 was found to be more effective on the mitochondrial functions than salinomycin.On the basis of the results so far obtained, the inhibitory effect of SY-1 on mitochondria is interpreted as a result of interaction with essential cations, especially with K+, in mitochondria. |
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| Keywords: | Albizzia julibrissin Durazz nyctinasty leaf-opening substance cis-p-coumaroylagmatine biological clock |
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