Isolation and Characterization of a Novel Antitumor Substance,Renastacarcin |
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| Authors: | Tetsuo Sasaki Noboru ōtake Akira Shimazu Hiroshi Yonehara Akio Kobayashi Hideaki Fukawa |
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| Institution: | 1. Institute of Applied Microbiology, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan;2. Central Research Laboratory, Nisshin Flour Milling Co,, Ltd., Tsurugaoka, Ohimachi Iruma, Saitama 354, Japan |
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| Abstract: | A new antitumor substance designated renastacarcin has been isolated from the cultured broth of Streptomyces violascens by means of DEAE-cellulose and Sephadex G-100 column chromatography. The homogeneity of renastacarcin was confirmed by electrophoreses on a polyacrylamide gel and a cellulose acetate membrane as well as by ultracentrifugal analysis. A sedimentation coefficient at 55,430 rpm was found to be 2.12S and the molecular weight was calculated to be 34,500. |
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| Keywords: | cholestane bisdesmoside Ornithogalum saundersiae cytotoxic activity HL-60 cells MOLT-4 cells |
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