内皮素在实验性主动脉狭窄—高盐摄入性高血压发病中的作用

内皮素是血管内皮释放的生物活性多肽,具有强烈的收缩血管和促进血管平滑肌细胞增生肥大的效应。本工作在大鼠腹主动脉狭窄和高盐摄入引起的高血压模型上,观察到高血压动物血浆内皮素水平成倍增加(9.70±0.68vs。假手术动物4.11±0.33pg/ml,P<0.01)。应用特异的内皮素抗血清治疗,显著缓解了动物血压的升高(18.97±1.32vs.27.33±0.90kPa,P<0.01)和心肌肥大损伤。实验结果提示:内皮素是高血压的重要发病因素之一;拮抗内皮素可能是高血压病防治的新途径。

ROLE OF ENDOTHELIN IN THE PATHOGENESIS OF RAT EXPERIMENTAL HYPERTENSION PRODUCED BY AORTA NARROWING AND SALINE UPTAKE

Endothelin is a bioactive polypeptide released from vascular endothelium, which has a strong action promoting vascular contraction, proliferation and hypertrophy of vascular smooth muscle cells. The present investigation was performed on the hypertensive rat produced by narrowing abdominal aorta and drinking saline. It was observed that the level of plasma endothelin in the hypertensive rats was doubled (9.70 +/- 0.68 vs. sham group 4.11 +/- 0.33 pg/ml, P < 0.01), and administration of specific endothelin-antiserum into hypertensive rats significantly attenuated the increase in the blood pressure (18.97 + 1.32 vs. 27.33 + 0.09 kPa in untreated hypertensive rats, P < 0.01), and dramatically ameliorated malfunction resulting from myocardial hypertrophy. The results suggest that endothelin is an important factor in the pathogenesis of hypertension, and that inhibition of endothelin action may be a new effective way in prevention and therapy of hypertension.