TC1(C8orf4) is upregulated by IL-1beta/TNF-alpha and enhances proliferation of human follicular dendritic cells |
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Authors: | Kim Youngmi Kim Jungtae Park Juhee Bang Seunghyun Jung Yusun Choe Jongseon Song Kyuyoung Lee Inchul |
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Affiliation: | Asan Institute for Life Sciences, University of Ulsan, College of Medicine, Seoul, Republic of Korea. |
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Abstract: | Follicular dendritic cells (FDC) play crucial roles in immune regulation. TNF-alpha has been shown to be essential to the FDC network. However, the molecular regulation of FDC proliferation has not been characterized. Here, we show that TC1(C8orf4), a novel positive regulator of the Wnt/beta-catenin pathway in vertebrates, is upregulated by IL-1beta and TNF-alpha in the human FDC-like line HK. TC1 enhances HK cell proliferation, while TC1-knockdown inhibits the proliferation induced by IL-1beta, suggesting a role of TC1 as a regulator of FDC proliferation. The regulation by pro-inflammatory cytokines suggests that TC1 might be implicated in linking local inflammation to immune response by stimulating FDC. |
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Keywords: | TC1(C8orf4) NF-kB IL-1β TNF-α Wnt/β-catenin pathway HK cell |
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