Evidence for a mutagenic effect of the narcotic antagonist, naltrexone, in germ cells of Drosophila. |
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Authors: | S Zimmering |
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Abstract: | The narcotic antagonist, Naltrexone, was tested for mutagenicity in Drosophila. The frequency of sex-linked recessive lethals at a non-toxic dose of 10 mg/ml was 0.43% (42 lethals in 9697 X-chromosomes tested) and 0.16% (19/11536) in the controls. The difference is statistically significant (P less than 0.001). Results from large-scale experiments testing for chromosome breakage and nondisjunction were negative. |
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