Antioxidant effect of homogenetisic acid on hydrogen peroxide induced oxidative stress in human lung fibroblast cells |
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| Authors: | Kyoung Ah Kang Sungwook Chae Kyung Hwa Lee Rui Zhang Myung Sun Jung Ho Jin You Jin Sook Kim Jin Won Hyun |
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| Affiliation: | (1) Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, 690-756 Jeju, Korea;(2) Department of Pharmacology, College of Medicine, Chosun University, 501-759 Gwangju, Korea;(3) Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 305-811 Daejeon, Korea |
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| Abstract: | Homogentisic acid was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and thus prevented lipid peroxidation in human fibroblast (WI 38) cells. The radical scavenging activity of homogentisic acid was found to protect WI 38 cells against hydrogen peroxide (H2O2) induced oxidative stress, via the activation of extracellular signal regulated kinase (ERK) protein. Homogentisic acid increased the activity of catalase. Hence, from the present study, it is suggested that homogentisic acid protects WI 38 cells against H2O2 damage by enhancing the intracellular antioxidative activity. |
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| Keywords: | homogentisic acid oxidative stress catalase |
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