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Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates
Authors:Jae-Won Shin  Joe SwiftIrena Ivanovska  Kyle R SpinlerAmnon Buxboim  Dennis E Discher
Institution:Molecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
Abstract:
Keywords:3D  three-dimensional  AFM  atomic force microscopy  Bleb  blebbistatin  BM  bone marrow  BMT  bone marrow transplantation  ECM  extracellular matrix  ESC  embryonic stem cell  G-CSF  granulocyte colony-stimulating factor  HSC/P  hematopoietic stem cell/progenitor  kPa  kilopascal  units of elasticity  MAL/MKL  megakaryocytic acute leukemia protein  MK  megakaryocyte  MLCK  myosin light chain kinase  MSC  mesenchymal stem cell  NMM-II  non-muscle myosin-II  OB  osteoblast  RBC  red blood cell  RLC  regulatory light chains  ROCK  rho-associated protein kinase  SDF-1  stromal derived factor-1  SRF  serum response factor  YAP  yes-associated protein
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