Molecular characterization of the iron-hydroxamate uptake system in Staphylococcus aureus |
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Authors: | Cabrera G Xiong A Uebel M Singh V K Jayaswal R K |
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Institution: | Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790-4120, USA. |
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Abstract: | To investigate iron uptake, a chromosomal locus containing three consecutive open reading frames, designated fhuC, fhuB, and fhuD, was identified in Staphylococcus aureus. Whereas the fhuC gene encodes an ATP-binding protein, fhuB and fhuD code for ferrichrome permeases and thus resemble an ATP-binding cassette transporter. A fhuB knockout mutant showed impaired uptake of iron bound to the siderophores but not of ferric chloride, suggesting that this operon is specific for siderophore-mediated iron uptake. |
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