Discriminative stimulus properties of the serotonergic agent 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) |
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| Authors: | R A Glennon |
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| Affiliation: | 1. Department of Nutrition and Health Sciences, Kainan University, Taoyuan 338, Taiwan;2. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan;3. PhD Program in Translational Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan;4. Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan;1. Department of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA;2. Department of Biology, Oglethorpe University, Atlanta, GA, USA;3. Section on Drug Design and Synthesis, National Institute on Drug Abuse and Chemical Biology Research Branch, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA |
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| Abstract: | Using a two-lever drug discrimination procedure, six rats were trained to discriminate 0.5 mg/kg of racemic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) from saline. Once trained, the animals demonstrated a dose-related decrease in discriminative performance upon administration of lower doses of DOI (ED50 = 0.16 mg/kg). DOI-stimulus generalization occurred with the putative 5-HT2 agonist DOM (ED50 = 0.49 mg/kg), but not with the 5-HT1A agonist 8-OH DPAT, or the 5-HT1B agonist TFMPP. Furthermore, the DOI stimulus could be antagonized by pretreatment of the animals with the 5-HT2 antagonist ketanserin. The present results, coupled with the prior demonstration that DOI possesses a significant affinity and selectivity for 5-HT2 binding sites, suggest that the discriminative stimulus effects of DOI may be 5-HT2-mediated. |
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