| Affiliation: | 1.Ludwig-Maximilians-Universit?t München, Department Biologie II,Planegg-Martinsried,Germany;2.Kirchhoff Institut für Physik,Universit?t Heidelberg,Germany;3.Institute of Stem Cell Research,GSF – National Research Center for Environment and Health,Neuherberg,Germany |
| Abstract: | Background Similarities as well as differences in higher order chromatin arrangements of human cell types were previously reported. For an evolutionary comparison, we now studied the arrangements of chromosome territories and centromere regions in six mouse cell types (lymphocytes, embryonic stem cells, macrophages, fibroblasts, myoblasts and myotubes) with fluorescence in situ hybridization and confocal laser scanning microscopy. Both species evolved pronounced differences in karyotypes after their last common ancestors lived about 87 million years ago and thus seem particularly suited to elucidate common and cell type specific themes of higher order chromatin arrangements in mammals. |
