Sealed with a Kiz: How Plk1 ensures spindle pole integrity |
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Authors: | Fry Andrew M Baxter Joanne E |
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Institution: | Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, United Kingdom. |
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Abstract: | The kinase Plk1 plays multiple roles in regulating mitotic progression, including stabilization of spindle poles, but its substrates are largely unknown. A new study by Yamamoto and coworkers has identified a centrosomal protein, Kizuna (Kiz), as a mitotic substrate of Plk1 (Oshimori et al., 2006). Phosphorylation of Kiz ensures the integrity of spindle poles in the face of severe pulling forces exerted by the chromosome-attached spindle microtubules. |
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