Tollip: a multitasking protein in innate immunity and protein trafficking |
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| Authors: | Capelluto Daniel G S |
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| Affiliation: | Protein Signaling Domains Laboratory, Department of Biological Sciences, Virginia Tech, 1981 Kraft Drive, Room 2007, Blacksburg, VA 24061, USA. capellut@vt.edu |
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| Abstract: | The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated innate immune responses. Tollip modulates TLR signaling and membrane trafficking processes through its interaction with both proteins and phosphoinositides. Here, I discuss the multitasking role of Tollip associated with its modular architecture. |
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