The cardiac effects of parathyroid hormone in the tiger frog, Rana tigrina |
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| Authors: | K W Chiu Y C Lee P K Pang |
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| Institution: | Department of Biology, Chinese University of Hong Kong, Shatin, N.T. |
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| Abstract: | 1. The cardiac effects of the N-terminal (1-34) peptide fragment of bovine parathyroid hormone bPTH-(1-34)] on isolated atria were examined in the frog, Rana tigrina. 2. bPTH-(1-34) produced dose-related inotropic response but no chronotropic response. This inotropic response varied at different times of the year. 3. The inotropic effect of bPTH-(1-34) was attenuated in the presence of verapamil and imidazole. 4. The mechanism of action of bPTH-(1-34) is probably a stimulation of calcium influx directly or indirectly via cAMP production. |
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