The Py235 proteins: glimpses into the versatility of a malaria multigene family |
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| Authors: | Grüner Anne Charlotte Snounou Georges Fuller Katy Jarra William Rénia Laurent Preiser Peter R |
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| Affiliation: | 1. Département d''Immunologie, Institut Cochin, Inserm U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France;2. Unité de Parasitologie Biomédicale & CNRS URA2581, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris cedex 15, France;3. Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK;4. School of Biological Sciences, Nanyang Technological University, 1 Nanyang Walk, Blk 5, level 3, Singapore 637616 |
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| Abstract: | Py235 rhoptry proteins, encoded by a multigene family of the rodent malaria parasite Plasmodium yoelii, combine a functional role in invasion with one of immune evasion, and have homologues in malaria parasites of humans. Investigations of Py235 are summarised and the perspectives for dissecting the molecular and biological mechanisms underlying these crucial phenomena are discussed. |
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