Redox processes of methionine relevant to beta-amyloid oxidation and Alzheimer's disease. |
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Authors: | Christian Sch?neich |
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Institution: | Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA. schoneic@ukans.edu |
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Abstract: | This minireview gives an overview over the oxidation mechanisms of methionine (Met) relevant for analogous processes which may lead to the oxidation of beta-amyloid (betaA) peptides. The Cu(II)-catalyzed oxidation of a C-terminal Met(35) residue in betaA peptides may be a key to the known propensities of these peptides to form H2O2 and free radicals. Though the reduction potentials of Cu(II) and Met would seem unfavorable, there are several structural features of betaA, which may promote a one-electron oxidation of Met. The potentially close association of the Met sulfur with the C=O group C-terminal of Ile(31) in the C-terminus of betaA may support the formation of an S-O bonded radical cation intermediate. Evidence for such S-O bond formation has recently been obtained for a model, N-acetylmethionine amide. Additional support for a potential catalytic role of an oxygen-containing functional group comes from numerous studies with organic model sulfides. |
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Keywords: | methionine methionine sulfoxide sulfide radical cations one-electron oxidation hydroxyl radical β-amyloid Alzheimer's disease aging |
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