Synthesis of 1,2-trans-disaccharides via sugar thio-orthoesters |
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Authors: | Leon V Backinowsky Yury E Tsvetkov Nikolay F Balan Narguiz E Byramova Nikolay K Kochetkov |
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Institution: | N. D. Zelinsky Institute of Organic Chemistry, Academy of Sciences of the U.S.S.R., Moscow U.S.S.R. |
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Abstract: | The reaction of sugar 1,2-thio-orthoesters in the d-gluco, d-galacto, d-manno, and l-rhamno series with primary and secondary trityl ethers of monosaccharides, in the presence of triphenylmethylium perchlorate as catalyst, affords, stereospecifically, derivatives of 1,2-trans-disaccharides in good yields. 4-Trityl ethers of benzyl 2-acetamido-3,6-di-O-acetyl-2-deoxy-α-d-glucopyranoside and methyl 2,3,6-tri-O-benzoyl-α-d-galactopyranoside exhibit low reactivity in glycosylation by thio-orthoesters. A reaction scheme for the glycosylation is discussed. |
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